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Biceps <t>brachii</t> muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)
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Biceps <t>brachii</t> muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)
Digital Electronic Densimeter Dma 4500 M, supplied by Anton Paar, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Biceps <t>brachii</t> muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)
Digital Microscope Dinolite Am4013mtl Fvw, supplied by AnMo Electronics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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IITC Life Science digital electronic von frey anesthesiometer model alemo 2450
Biceps <t>brachii</t> muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)
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Marathon Watch Company Ltd electronic digital micrometer model marathon watch
Biceps <t>brachii</t> muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)
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Cooper Instrument digital probe tm99a
Biceps <t>brachii</t> muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)
Digital Probe Tm99a, supplied by Cooper Instrument, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Biceps brachii muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)

Journal: BMC Neurology

Article Title: A novel variant in the tropomyosin 3 gene presenting as an adult-onset distal myopathy - a case report

doi: 10.1186/s12883-023-03225-3

Figure Lengend Snippet: Biceps brachii muscle biopsy from patient. A There is variation in fibre size consistent with a chronic myopathy. B No inclusions are seen on Gömöri-trichrome stain. C and F Some fibres showed pale central areas on NADH stain and SDH stains (arrows) but not on E COX staining, suggesting regions with reduced oxidative enzyme activities. D There is predominantly type 2 fibre atrophy with no fibre type predominance. ( A : Hematoxylin and eosin (HE) stain, original magnification × 10; B : Gömöri-trichrome stain, original magnification × 20; C : NADH-TR stain, original magnification × 10; D : ATPase pH9.4, original magnification × 10; E : COX stain, original magnification × 10; F : SDH stain, original magnification × 10; A - F : scale bar 100mm; picture resolution A - F : 1280 x1024)

Article Snippet: Biceps brachii muscle biopsy (Fig. ; light microscope model: NI-U, Nikon, camera model: Nikon imaging device, DS-Camera, controller: DS-03, DS-Fil camera software: NIS-Elements BR4.2; Electron microscope model: JEOL JEM2100, camera model: Gatan SC1000 CCD camera, acquisition software: Gatan Microscopy Suite Digital micrograph) showed variation of muscle fibre size (Fig. A).

Techniques: Staining, H&E Stain